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Additionally, SARS-CoV-2 with the naturally occurring mutations to E484, F490, Q493 or S494 of the S protein was found to escape from potential therapeutic antibodies such as C121 and C144 (ref

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NMR studies show that in model peptides, the proton is predominantly on the ε 2 , N 3 , or tele N in the imidazole ring, as it has a pK a 0 \)