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Proteins secreted by CAFs, such as matricellular SPARC (expressed in 88% of CAFs) and matrix metalloproteinases (MMP), enable the mobility and invasiveness of TNBC cells by inhibiting cell adhesion (37)
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Upon binding to its ligands, CD80 or CD86, CTLA-4 recruits phosphatases such as SHP-2 and protein phosphatase 2A (PP2A) to its cytoplasmic domain
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