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Additional antioxidants like ascorbic acid (vitamin C) help release the NO that was bound to glutathione, recapturing the NO that the body has already produced.[52] This may be one mechanism by which antioxidants and natural substances like pomegranate and quercetin—which provide high levels of polyphenols, which are natural antioxidants—also have a positive effect on ED of a vascular etiology.[53],[54],[55] Antioxidants are also important for the formation of the NOS enzyme as well as maintaining it in its active, coupled state.[56],[57] When NOS becomes uncoupled, it reduces molecular oxygen to superoxide (a damaging free radical) instead of NO.[58] This may be one means by which the French Maritime pine bark [CD2] also has a positive impact on erectile function

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Two-sided t-test was used to determine statistical significance between groups (* P = 0.0264, ** P = 0.0031, ** P = 0.0083, ** P = 0.0033, ** P = 0.0093, * P = 0.0199, * P = 0.0480)