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Of note, supporting the role of ATP and the consequent P2X7R activation, the SOD1 G93A astrocyte-mediated MN death was significantly prevented by depleting ATP with apyrase or by blocking the P2X7R with the antagonist brilliant blue G (BBG) [254]

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This type of imbalance can lead to many common pathologies like tendinopathies, bursitis’, muscle strains and even degenerative changes or osteoarthritis