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Impaired individuals exhibit hypomethylation of CpG sites in the CCL11 promoter region, which are then hypermethylated upon supplementation with B12 In impaired individuals, three CpG sites exhibited hypomethylation when compared to the non-impaired group
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A phase IV study demonstrated Endostatin could influence melanoma invasion by regulating T Cell activation (Nyakas et al., 2019)
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