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In addition to their cell defense function, local recruitment of NADPH oxidases, including non-phagocytic oxidases, has more recently been implicated in the production of ROS by growth factors and cytokines, though some of these may produce ROS by other means 24

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Studies have shown that inhibition of p53 in tumor cell growth is related to increased ferroptosis sensitivity ( via system Xc(-) or by upregulating recombinant spermidine/spermine N1-acetyltransferase 1 (SAT1) downstream of p53, which is involved in polyamine metabolism ( Transcription Factor Pathways A major transcription factors, such as nuclear factor-erythroid 2-related factor 2 (NFE2L2, also known as NRF2) ( in vitro and in vivo (Figure 2)

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