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3.6.5 Redox regulation DTP cells survive drug-induced oxidative stress by increasing the expression of enzymes such as glutathione peroxidase 4 (GPX4) and aldehyde dehydrogenase (ALDH), scavenging harmful substances generated by oxidative stress, and maintaining intracellular redox balance (72, 114)
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Moreover, NADPH production by the oxidative branch of the PPP is increased in many types of cancer cells [32,53]
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