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Since the time course of the changes in ERK1/2 activity generally correlate with the development of morphine tolerance, it has been assumed (perhaps prematurely) that ERK1/2 activation plays a role in morphine tolerance

Adrenal

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ATD - LBD interactions and allosteric coupling The molecular puzzle of how allosteric inhibitors such as Ro25-6981 and ifenprodil promote closure of the ion channel gate despite the binding of agonists to their cognate LBD dimers must be resolved, at least in part, through communication between the ATD and LBD layers and perturbation of the LBD layer from an ‘active’ conformation to an ‘inactive’ state

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