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In MASLD, reduced SIRT1 activity leads to hyperacetylation and stabilization of PLIN2 and PLIN3, effectively “locking” lipid droplets and impairing lipophagic clearance, exacerbating triglyceride accumulation
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The rats that were aged 8 weeks and weighed 280±20 g underwent Ferrostatin-1 (Fer-1) or short hairpin (sh)RNA treatments, whereas the rats that were aged 6 weeks and weighed 130-150 g were treated with for adeno-associated virus
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