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NAMPT expression is significantly reduced in animal models of chronic pressure overload induced heart failure or dilated cardiomyopathy caused by genetic mutations, [28, 29, 31]
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All studies mentioned above indicate that the search for an optimal dose for LD for CAR-T rather reflected a ‘trial and error ‘strategy based on many drugs used in allogeneic stem cell transplantation and was not based on actual pharmacokinetic studies
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