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BM-derived MSCs have been found to have significant paracrine functions, including the secretion of angiogenic factors, growth factors, and cytokines 98
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They reported that p53 suppresses accumulation of cytoplasmic chromatin fragments (CCF), including DNA damage signaling marker γH2A.X, and its downstream inflammatory phenotype (e.g., SASP) of monocytes and macrophages in liver
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