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Ang-(1−7) interact with AT2 receptors and Mas G protein-coupled receptors (MasR), which are present in the heart, vasculature, and kidneys, promoting vasodilation, nitric oxide production, and increased arterial baroreflex sensitivity [84]
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CB 2 receptor activation CB 2 is expressed mostly in cells and tissues of the immune system, with the highest number being found in the spleen, lymph nodes, and blood, namely in the T and B lymphocytes [22,23], although some evidence exists that CB 2 receptors are also found in the peripheral nervous system and even in the microglia population [24]
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