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ABBREVIATIONS 5-HT serotonin (5-hydroxytryptamine) α-KG α-ketoglutarate ACC anterior cingulate cortex AMPA receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor CBT cognitive-behavioral therapy CSF cerebrospinal fluid CSTC cortico-striato-thalamo-cortical Cys cystine D1 receptor dopamine receptor type 1 D1CT-7 transgenic mice expressing cholera toxin under the D1 promoter D2 receptor dopamine receptor type 2 DCS D-cycloserine D-Ser D-serine DSM-IV diagnostic and statistical manual of mental disorders, 4 th edition EAAC1 excitatory amino acid channel 1 (equivalent to EAAT3) EAAT1–3 excitatory amino acid transporters 1–3 FDA U.S Food and Drug Administration GABA gamma-aminobutyric acid GAD generalized anxiety disorder GAD glutamic acid dehydrogenase GAT GABA transporter GLAST glutamate-aspartate transporter (equivalent to EAAT2) Gln glutamine GLT-1 glutamate transporter 1 (equivalent to EAAT1) Glx MRS measurement of glutamate, glutamine, and related molecules Gly glycine Gly-T glycine transporter GPe globus pallidus, pars externa GPi globus pallidus, pars interna GriK glutamate receptor gene, ionotropic, kainite subtype GriN2B glutamate receptor, ionotropic, NMDA, subunit 2B – gene encoding the NR2B subunit MDD major depressive disorder mGluR metabotropic glutamate receptor MK-801 an NMDA channel blocking drug MRS magnetic resonance spectroscopy MSN medium spiny neuron NAC N-acetylcysteine NMDA receptor N-methyl-D-aspartate-type glutsmate receptor NR1 obligate subunit of the NMDA receptor NR2B 2B subunit of the NMDA receptor OCD obsessive-compulsive disorder OFC orbitofrontal cortex PET positron emissio tomography PSD postsynaptic density RNA ribonucleic acid SAPAP3 SAP90-PSD-95 associated protein 3 Slc1A1 solute carrier family gene 1A1 (gene encoding EAAT3/EAAC1 protein) Slitrk5 gene for Slit and Trk-like protein 5 SNc substantia nigra, pars compacta SNP single nucleotide polymorphism SNr substantia nigra, pars reticulata SSRI selective serotonin reuptake inhibitor STN subthalamic nucleus Suc succinate TCAn tricarboxylic acid cycle (Krebs cycle) vGluT vesicular glutamate transporter XC- cystine-glutamate transporter Y-BOCS Yale-Brown Obsessive Compulsive Scale Footnotes Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication