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These findings are consistent with their well-established inhibitory potency toward CYP2D6, an enzyme that contributes meaningfully to HRM clearance ( Although moderate DDIs are not always considered clinically prohibitive, their significance must be evaluated in light of the underlying pharmacology
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Public involvement and engagement We invited public members from HDR UK’s Public Advisory Board [28] to contribute to developing the DAA template, by participating in an activity designed according to the UK Standards for Public Involvement [29]
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