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By using a reducible disulfide linker, we built in a redox-sensitive release mechanism to facilitate intracellular release of the unmodified NMDA receptor antagonist, enabling the combined cellular actions of GLP-1 receptor agonism and NMDA receptor antagonism
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Cagrilintide has shown promising results in animal studies and clinical trials, demonstrating significant weight loss and improved glycemic control in obese patients with or without type 2 diabetes
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