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Although the Us6 viral gene, which encodes the gD has also been reported to block apoptosis in these cells, the molecular mechanism involved in inhibiting apoptosis by this viral glycoprotein has not been completely elucidated, although an association with NF-κB activation and increased expression of NF-κB-dependent anti-apoptotic genes, such as c-IAP2, FLIP and survivin has been suggested as a mode of action in U937 monocytoid cells (Medici et al., 2003