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The application of multi-OMICS approaches are gaining acceptance in the regulatory community to provide information on a chemical’s hazard and risks though their mode-of-action (MOA), however, its utility in a AOP building context are still limited

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miR-483-3p upregulation reduces human NK cell cytotoxicity Given the finding that endogenous IGF-1 is critical to the cytotoxic activity of human NK cells and that miR-483-3p can regulate IGF-1 expression, we hypothesized that miR-483-3p may regulate NK cell cytotoxic activity, at least in part, through IGF-1