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Prominent mTORC1 inhibitors currently in PKD clinical trials include rapamycin itself, analogues such as sirolimus and everolimus [108], as well as metformin, a known AMP-activated protein kinase (AMPK) activator that also downregulates S6K phosphorylation [109, 110]
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Some protocols add a GHRP to CJC-1295 with DAC, a modified version that remains active in circulation for days rather than minutes
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