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ROLE OF ROS IN PATHOPHYSIOLOGY ROS act as signaling molecules in a variety of intracellular signaling pathways, triggering specific target proteins such as transcription factors, kinases, and phosphatases to further orchestrate cellular processes and thus regulate cell cycle progression (proliferation or arrest), differentiation, quiescence, senescence, or apoptosis (Figs

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Multiple studies have shown that mTOR regulates the biological functions of cells by regulating downstream transcription factors such as HIF1α、MAF1、SERBPs [25]