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Proportion of delays significantly decreased from 12.7% to 4.1% between 2018 and 2024 (p 17 years, GCS⩾6, requiring mechanical ventilation were randomized within 18 hours of symptoms to either 72 hours of TTM to moderate hypothermia (MH = 32-34°C) followed by a controlled rewarming at 0.05-0.1°C/hour and maintenance of normothermia (NT = 36-37°C) for up to 7-days or TTM to NT (36-37°C) for 7-days using endovascular/surface cooling