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Even before, in the BPC 157/serotonin relations, after peripheral application, particular effect on various brain areas (i.e., especially the serotonin release from the nigrostiratal area) [24] was associated with particular therapy effect, such antidepressant activity (Porsolt’s helplessness) and counteracted serotonin syndrome (for review, see [8,9,10])

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Studies confirmed that animals lacking these receptors showed no lipolytic response, validating this as the primary pathway