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Methods Study design In the first step of this study, we investigated the mRNA expression of 20 genes in ACF tissues as targets for molecular imaging: GSTP1, glucose transporter-1 (Glut-1), c-MET, β-catenin, SLC7A7, Cadherin-1, EGFR, Fzd1, inducible nitric oxide synthase (iNOS, NOS2), CD44, cyclooxygenase-2 (COX-2), c-KIT, EPHB3, CD24, Glut-4 (SLC2A4), ADAM17, prostaglandin E receptor 2 (PTGER2), cyclin dependent kinase 4 (CDK4), cathepsin B1, and glutathione peroxidase-2 (GPX-2)

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The increased ROS promote ovarian aging through various signaling pathways