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Propionate and acetate are additional substrates for the TCA cycle and ameliorate metabolic and intestinal diseases by activating intestinal gluconeogenesis (like microbiome-derived succinate 117 ) 118 and by enhancing innate immune responses via free fatty acid receptor 2 (FFAR2)-signaling 119
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Whilst showing potential healing properties in animal model studies and lab experiments, it remains a research chemical
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