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Erastin, as a small-molecule ferroptosis inducer, works by inhibiting the system Xc − transporter-an amino acid antiporter responsible for exchanging extracellular cystine for intracellular glutamate (11)-leading to depletion of intracellular glutathione (GSH), indirectly inactivating glutathione peroxidase 4 (GPX4), and ultimately triggering ferroptosis (12)
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APOE ε4 microglia presented decreased process length and were fewer in number (Lin et al., 2018), which might be associated with decreased phagocytic capabilities, specifically phagocytosis of Aβ
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