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Considering the estrogen receptor, hypermethylation of the estrogen receptor 1 ( ESR1 ) promoter by mechanisms involving zinc finger E-box-binding homeobox 1 (ZEB1) and interleukin-1β (IL-1β) reduces its transcription and, therefore, ERα protein expression which confers resistance to tamoxifen treatments [149,150,151]
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doi: 10.1371/journal.pone.0068322 256 SrikanthaPMohajeriMH
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