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The beneficial effects (down-regulation of inflammatory factors) of some natural compounds (such as sinomenine, tetrandrine and paeoniflorin) in RA are attributed to the reduction of NF-κB p65 signal

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These observations culminated in the conclusion that MeHg-L-cysteine conjugate (MeHg-Cys) is a substrate for the LAT1 system, which actively transports MeHg across membranes and is responsible, at least in part, for the high Hg levels found in the brain after exposures