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moreover, in the context of immunotherapy and targeted agents there is compelling translational evidence primarily from murine models and observational cohorts in other cancers that specific taxa enhance antitumour immune responses and predict checkpoint inhibitor efficacy, suggesting analogous potential in subsets of breast cancer patients, particularly those receiving immunomodulatory regimens (177)

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Using in silico design, structure–activity relationships (SARs), chemical optimization, cell-based assays and in vivo experiments, we identified and characterized the first-in-kind small-molecule inhibitors of STX7–Munc13-4-dependent endosomal maturation and signaling for use in immune cells that contribute to systemic inflammation