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It is noteworthy that endurance exercise increases both cytosolic and mitochondrial GPX activity (195)
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The trial did not meet its primary end point of median PFS (11.9 months vs 11.9 months), but it revealed that the addition of nivolumab causes improvements for PFS, median OS (i.e., 29.2 months), ORR (i.e., 46% vs 60%), and DCR (i.e., 84% vs 91%) after 12 months, when compared to the control arm
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