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Cleavage of the signaling receptor for BDNF, the tropomyosin receptor kinase B-full length (TrkB-FL), occurs in human tissue and in animal models of brain diseases [232]
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These observations culminated in the conclusion that MeHg-L-cysteine conjugate (MeHg-Cys) is a substrate for the LAT1 system, which actively transports MeHg across membranes and is responsible, at least in part, for the high Hg levels found in the brain after exposures
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