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Due to its role in various physiological processes, many SIRT1 activators are currently available that have limited specificity, low bioavailability and varying degrees of blood–brain barrier penetration, and prolonged or excessive activation of SIRT1 can result in off-target metabolic effects
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Although currently not found to be directly linked to the activity of Grxs, ADP-ribosylation factor 6 is S-glutathionylated under ferroptotic conditions, regulating localization of the transferrin receptor on the cell membrane and transferrin uptake [131]
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