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This indicated that the TrxR1/Gsr-null livers excrete much more oxidized GSSG than do wild type livers, which likely is critical for sustaining the reduced state of the intracellular [GSH/GSSG] redox couple in the absence of GSSG-reductase activity [107]
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Instead, carbonylation is likely to occur preferentially within cancer cells, where upregulated heme oxygenase-1 (HO-1) provides a continuous flux of free CO
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