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The activation of thioredoxin superfamily proteins through NRF2 activators (such as omaveloxolone, resveratrol, sulforaphane and melatonin) can represent promising therapeutic options in FRDA, and, as such, they have been or are already being subject of pre-clinical and clinical trials (Table 1)
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Thus, the designed GLP-1 albumin fusions stimulate glucose-dependent insulin secretion in a GLP-1R-dependent manner
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