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The mature adipocytes secrete BMP4 that triggers preadipocyte differentiation by inducing the separation of Wnt1 inducible-signaling pathway protein 2 (WISP2) and zinc finger protein 423 (ZNF423), allowing ZNF423 to translocate into the nucleus and activate peroxisome proliferator-activated receptors (PPARγ) and downstream cascade including CCAAT/enhancer-binding proteins β (C/EBPβ), δ, and α [41, 42] ( Figure 1 )

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This is the mechanisms that underlies the reward and reinforcing effects of ethanol