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While adaptive immune cells mount a delayed, antigen-specific response that results in long-term memory, innate immunity cells respond promptly and in a non-antigen-specific manner ( Immunity exhibits a notably translational nature, operating throughout the body, exchanging information, interacting with most systems, and being significantly affected by the likes of stress, diet, and exercise ( The immune system also reacts and is therefore sensitive to various types of stressors—psychological, physical, and local environmental (e.g., oxidative and radiation exposure)

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A histone modification is a covalent post-translational modification (PTM) to histone proteins which includes methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation