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Cytokines like IL-6, TNF-α eventually leads to the release of reactive oxygen species (ROS) and reactive nitrogen species from the mitochondria which is responsible for end-organ damage, thrombosis, and shock [Figure 1].[1] Presence of comorbidities like hypertension, diabetes mellitus, ischemic heart disease, respiratory ailments, chronic kidney disease, obesity and the elderly age groups are the ones with a low baseline immunity and thus are easily susceptible to develop serious illness once COVID-19 positive

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The rats were euthanized after seven days of treadmill training by injecting potassium chloride (1.5 mg/kg) under deep anesthesia