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Recent investigations further indicated that UA may operate as a protective factor mediated through astroglia for dopaminergic neurons from glutamate toxicity ( + -induced depolarization amplifies neuroprotection provided by UA through a mechanism involving Ca 2 elevation and extracellular signal-regulated kinases½ (ERK 1/2 ) activation ( Figure 3 )
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In Vitro Cell Dev Biol 1989;25:358-364
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