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When the liver loses its average mass, volume, or physiological and biochemical functions due to various reasons, HGF binds to its specific receptor c-Met (cellular mesenchymal-epithelial transition) and transmits the signals into the cells, and triggers the intrinsic kinase activity of c-Met
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We use uricase enzymes like rasburicase and pegloticase, which convert uric acid into allantoin, a compound that is easily excreted by the kidneys, lowering serum uric acid levels and preventing new crystal formation
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