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• Headache • Mild diarrhea • Mild pain or redness at the injection site • Nausea Serious or rare side effects – Stop taking Vitamin B12 Injection and seek immediate medical attention right away if you experience any of the following: • Allergic reactions, including angioedema, hives, and trouble breathing • Signs of heart problems, including swelling, rapid weight gain, and shortness of breath • Signs of hypokalemia, including muscle weakness, slow or irregular heartbeat Contraindications: This is not an exhaustive list of contraindications

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For its part, transforming growth factor β (TGF-β) is one of the major cytokine produced by T cells compared to other body cells, which have a positive effect on cartilage remodeling by upregulating differentiation-related transcription gene Sox9 and downregulating IL-6 receptor expression in chondrocytes, thereby maintaining cartilage homeostasis [9,10]