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The technique can reveal the presence of disordered regions and the flexibility of multidomain proteins by observing characteristics, such as large R g , expanded distance distribution functions (p(r)), and, for highly disordered proteins, the lack of a characteristic bell-shaped peak in Kratky plot (Bernado and Svergun, 2012)

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When a patient presents with suggestive symptoms, the GP will typically conduct a thorough history exploring dietary habits, gastrointestinal symptoms, medicine use, and relevant medical conditions