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Our published report has shown that PABA/NO causes intracellular NO levels to rise above a certain threshold through eNOS activation with a subsequent link between S-nitrosylation and S-glutathionylation (166)
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Alpha-lipoic acid Increased oxidative stress caused by free radical formation and defects in antioxidant defense related to hyperglycemia is thought to cause endoneurial hypoxia and nerve dysfunction, which contribute to DPN [61]
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