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In addition, IL-12 can stimulate the proliferation of CD8+ T cells when antigen levels are low.[ref] (IL-2 genes, IL-15 genes) Glutamate receptors: A 2025 study adds in a little more detail on CD8+ T cell activation
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The pathogenic processes involved are multifactorial, encompassing direct impacts on the host and cooperative interactions with indigenous commensal microbiota that can lead to immune dysregulation
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