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In M1/M2 macrophages, Th2 cells, and airway epithelial cells, 4-OI reduces eosinophil-attracting chemokines, partly via NRF2 activation
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Yet, more recently, a metabolomic analysis reveals the importance of glutamine uptake by ASCT2 and its conversion into ROS-producing intermediate metabolite α-Ketoglutarate as marker of sensitivity during sulfasalazine xCT-inhibition cell death in head and neck squamous cells carcinoma (46)
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