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In 2020, the number of deaths due to CRC was estimated at 935,000 worldwide (50% occurring between ages 50 and 74) and will reach 1.6 million deaths per year by 2040 according to the WHO
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Even more, the glucose tolerance test (GTT), the release of insulin and the insulin tolerance test (ITT) after the first dose of ASO, showed that targeting Mat1a , prevented the impairment in glucose disposal before the marked body weight loss (Supplementary Fig
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