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In the first article, plain lidocaine injections had no effect so it would seem, the B12 was the useful agent in the second study
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Regarding ECM metabolism, cuproptosis suppresses anabolic genes (COL2A1, ACAN) while upregulating catabolic enzymes (MMP-3, MMP-13, ADAMTS-5), disrupting the synthesis-degradation equilibrium and accelerating cartilage structural deterioration (Che et al., 2024)
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