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Therefore, lack of control of latency I cells leads to persistent infection, where chronic exposure to these viral antigens could lead to a “depletion” of antiviral T cells, as occurs in chronic infections where the individual fails to generate a robust antiviral response [227]
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In contrast, SHIN1 did not restore differentiation in IL-22-treated keratinocytes in vitro, likely reflecting the severe growth impairment induced by SHMT inhibition under these conditions
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