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Of note, the direct evidence linking barrier dysfunction to L-valine malabsorption derives from the mouse model rather than the human cohort, so the integrated pathway should be regarded as mechanistically plausible but not yet established in humans (Zhou W

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Many factors contribute to the development of fibromyalgia in a unique manner: genetic predisposition, personal experiences, emotional–cognitive factors, the mind–body relationship and a biopsychological ability to cope with stress