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Several metabolic pathways are implicated in regulating ferroptosis, including the FSP1/coenzyme Q axis, the GCH1/BH4/DHFR axis, and the cysteine /GSH /GPX4 axis

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7.3 Ongoing challenges and future directions The translation of ferroptosis-targeted therapies faces several significant challenges that require careful consideration: 7.3.1 Nanocarrier delivery challenges While nanocarriers offer promising targeting capabilities, they face substantial translational hurdles including potential immunogenicity, nebulizer compatibility and stability, batch-to-batch consistency in manufacturing, and difficulties achieving uniform deep lung penetration and cellular uptake across different airway regions and cell types