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To test this, we treated Hs 578T cells with amino-oxyacetic acid (AOAA) and I3MT-3, pharmacological inhibitors of endogenous H 2 S-producing enzymes, and observed no decrease in NRF2 expression (Fig

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For example, in Foxp3-specific HIF-2α-knockout mice, tumor growth was slowed, potentially owing to the elevation of HIF-1α after HIF-2α deletion, resulting in impaired Treg immunosuppressive function