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When polyunsaturated fatty acids stimulate cells to produce RSL-3 to induce ferroptosis, monounsaturated fatty acids like oleic acid may neutralize and protect cells from ferroptosis (Yang et al., 2014)
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Most remarkably, TCGA found that somatic mutations in Keap1 are the second most common genetic lesion in lung adenoma carcinoma and the fourth most common in lung squamous cell carcinoma, whereas gain-of-function DLG and ETGE hot-spot mutations in NFE2L2 are the sixth most common in lung squamous cell carcinoma [415]
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