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Therapeutic translation bottlenecks are prominent: compounds effective in preclinical studies (e.g., andrographolide) often fail in human trials, as animal models cannot replicate patients’ individual differences and complex pathology (124)
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The presence of type I collagen β-isomerization of C-telopeptide in the bone matrix is considered to induce OC activation, and its content is three times greater in aged bones than in young bones
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